Salvage Treatment of Refractory HSV Oral Lesions with Pritelivir in Allogeneic Hematopoietic Cell Transplant Recipients
Davide Bosetti, Chiara Bernardi, M Maulini, Federica Giannotti, Anne‐Claire Mamez, Stavroula Masouridi‐Levrat, Yves Chalandon, Dionysios Neofytos
Abstract
We present two allogeneic hematopoietic cell transplantation recipients (HCTr) treated with pritelivir for acyclovir-resistant/refractory (r/r) HSV infection based on the expanded access program of the pritelivir manufacturer. Outpatient treatment with pritelivir was administered, with partial response by week 1 of treatment and complete response by week 4 of treatment in both patients. No adverse events were noted. Pritelivir appears to be an effective and safe option for the management of acyclovir-r/r HSV infections in highly immunocompromised patients in an outpatient setting.
Topics & Concepts
Refractory (planetary science)MedicineAdverse effectHematopoietic cellSalvage therapyHematopoietic stem cell transplantationTransplantationHSL and HSVInternal medicineImmunologySurgeryHaematopoiesisChemotherapyStem cellVirusBiologyGeneticsAstrobiologyVirus-based gene therapy researchHerpesvirus Infections and TreatmentsAnimal Virus Infections Studies