Photo/N-Heterocyclic Carbene Co-catalyzed Ring Opening and γ-Alkylation of Cyclopropane Enal
Lei Dai, Song Ye
Abstract
An unprecedented photo/NHC-co-catalyzed ring-opening C-C bond cleavage of cyclopropane enal and the following γ-alkylation with a halogenated compound via radicals were established, affording the corresponding γ-alkylated α,β-unsaturated esters in moderate to good yields.
Topics & Concepts
CyclopropaneChemistryAlkylationCarbeneCatalysisRing (chemistry)Bond cleavageMedicinal chemistryRadicalCleavage (geology)Organic chemistryFracture (geology)EngineeringGeotechnical engineeringCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry