High-intensity aerobic, but not resistance or combined, exercise training improves both cardiometabolic health and skeletal muscle mitochondrial dynamics
Gregory N. Ruegsegger, Mark W. Pataky, Suvyaktha Simha, Matthew M. Robinson, Katherine A. Klaus, K. Sreekumaran Nair
Abstract
We assessed the effects of 12 wk of supervised high-intensity interval training (HIIT), resistance training, and combined training (CT) on skeletal muscle mitochondrial abundance and markers of fission and fusion. HIIT increased mitochondrial area and size and promoted protein changes indicative of increased mitochondrial fusion, whereas lessor effects were observed after CT and no changes were observed after RT. Furthermore, increased mitochondrial area and size after HIIT associated with improved mitochondrial respiration, cardiorespiratory fitness, and insulin sensitivity.
Topics & Concepts
Cardiorespiratory fitnessHigh-intensity interval trainingSkeletal muscleInterval trainingAerobic exerciseInsulin resistanceMitochondrial fissionEndurance trainingmitochondrial fusionInternal medicineMitochondrionExercise physiologyResistance trainingMedicineBiologyEndocrinologyCardiologyMitochondrial DNAInsulinBiochemistryGeneCardiovascular and exercise physiologyAdipose Tissue and MetabolismMitochondrial Function and Pathology