An engineered cascade-sensitized red-emitting upconversion nanoplatform with a tandem hydrophobic hydration-shell and metal-phenolic network decoration for single 808 nm triggered simultaneous tumor PDT and PTT enhanced CDT
Yameng Li, Yingjie Ding, Yifan Zhang, Zhiyue Sun, Jiao Liu, Mengxia Dai, Jiayi Feng, Bin Li, Chaozhan Wang, Yinmao Wei, Jiwei Shen
Abstract
in PDT. The as-designed UCFS@Fe-TA thus can achieve a single 808 nm triggered simultaneous PDT and PTT enhanced CDT, leading to a PTT-assisted reactive oxygen species storm for efficient tumor suppression. Such a design also renders the nanoplatform lower cell dark toxicity. In addition, the single excitation-triggered multimodal therapy mode might address the excitation wavelength mismatch issue in dual laser-triggered PTT/PDT mode. This study has therefore presented an efficient nanotherapeutic platform enabling synergistic multimodal tumor therapies with high biocompatibility.
Topics & Concepts
TandemPhoton upconversionCascadeMaterials scienceMetalShell (structure)PhotochemistryChemical engineeringChemistryNanotechnologyOptoelectronicsComposite materialChromatographyLuminescenceEngineeringMetallurgyNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsLanthanide and Transition Metal Complexes