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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

Pierre Tonnerre, David Wolski, Sonu Subudhi, Jihad Aljabban, Ruben C. Hoogeveen, Marcos Damasio, Hannah K. Drescher, Lea M. Bartsch, Damien C. Tully, Debattama R. Sen, David J. Bean, Joelle Brown, Almudena Torres-Cornejo, Maxwell Robidoux, Daniel Kvistad, Nadia Alatrakchi, Ang Cui, David Lieb, James A. Cheney, Jenna Gustafson, Lia Laura Lewis‐Ximenez, Lucile Massenet-Regad, Thomas Eisenhaure, Jasneet Aneja, W. Nicholas Haining, Raymond T. Chung, Nir Hacohen, Todd M. Allen, Arthur Y. Kim, Georg M. Lauer

2021Nature Immunology115 citationsDOIOpen Access PDF

Topics & Concepts

ImmunologyCytotoxic T cellBiologyCD8Chronic infectionAntigenT cellPhenotypeCellStimulationVirologyImmune systemNeuroscienceIn vitroGeneGeneticsImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory | Litcius