Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex
Kane T. McQuaid, Shuntaro Takahashi, Lena Baumgaertner, David J. Cardin, Neil G. Paterson, J.P. Hall, Naoki Sugimoto, Christine J. Cardin
Abstract
ion at the other end of the G-quartet stack, which also coordinates three thymine residues. In a comparative ligand-binding study, we showed, using a Klenow fragment assay, that this complex is the strongest observed inhibitor of replication, both using the native human telomeric sequence and the modified sequence used in this work.
Topics & Concepts
ChemistryRutheniumG-quadruplexCombinatorial chemistryStereochemistryCatalysisOrganic chemistryDNABiochemistryDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesMolecular Junctions and Nanostructures