Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice
Chhinder P. Sodhi, Raheel Ahmad, William B. Fulton, Carla M. Lopez, Benjamin O. Eke, Daniel Scheese, Johannes W. Duess, Steve N. Steinway, Zachariah Raouf, Hannah Moore, Koichi Tsuboi, Maame Efua Sampah, Hee‐Seong Jang, Rachael H. Buck, David R. Hill, Grace M. Niemiro, Thomas Prindle, Sanxia Wang, Menghan Wang, Hongpeng Jia, Jonathan Catazaro, Peng Lu, David J. Hackam
2023American Journal of Physiology-Gastrointestinal and Liver Physiology26 citationsDOIOpen Access PDF
Abstract
This study reveals that the administration of human milk oligosaccharides, which are present in human breast milk, can interfere with the proinflammatory gut-brain axis and prevent neuroinflammation in the setting of necrotizing enterocolitis, a major intestinal disorder seen in premature infants.
Topics & Concepts
Necrotizing enterocolitisProinflammatory cytokineMedicineNeurotrophic factorsNeuroinflammationBrain-derived neurotrophic factorNeuroprotectionMyelinBrain damageInflammationCorpus callosumCentral nervous systemInternal medicineEndocrinologyImmunologyPathologyReceptorInfant Nutrition and HealthInfant Development and Preterm CareNeonatal Respiratory Health Research