Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
David J. Krus, Fredrik Kahn, Bo Nilson, Torgny Sunnerhagen, Magnus Rasmussen
Abstract
Non-β-hemolytic streptococci (NBHS) cause infective endocarditis (IE) and a short blood culture time to positivity (TTP) is associated with risk of IE in bacteremia with other pathogens. In this retrospective population-based cohort study, we investigate if TTP is associated to IE or mortality. Of 263 episodes with NBHS bacteremia, 28 represented IE and the median TTP did not differ significantly between episodes with IE (15 h) and non-IE (15 h) (p=0.51). TTP was similar among those who survived and those who died within 30 days. However, TTP significantly differed when comparing the different streptococcal groups (p<0.001).
Topics & Concepts
BacteremiaInfective endocarditisMedicineRetrospective cohort studyEndocarditisInternal medicineBlood cultureMedical microbiologyCohortStreptococcaceaeCohort studyPopulationGastroenterologyImmunologyMicrobiologyAntibioticsBiologyEnvironmental healthInfective Endocarditis Diagnosis and ManagementStreptococcal Infections and TreatmentsBacterial Identification and Susceptibility Testing