Increasing the functional density of threose nucleic acid
Biju Majumdar, Daisy Sarma, Yutong Yu, Adriana Lozoya‐Colinas, John C. Chaput
Abstract
) for engineered versions of TNA aptamers carrying chemotypes at both pyrimidine positions as compared to their singly modified counterparts. These findings expand the chemical space of evolvable non-natural genetic polymers by offering a path for improving the quality of biologically stable TNA aptamers for future clinical applications.
Topics & Concepts
Nucleic acidAptamerPolymeraseChemistryPrimer extensionCombinatorial chemistryDNABiochemistryNucleosideCytidinePrimer (cosmetics)DNA polymeraseNucleoside triphosphateStereochemistryBiologyEnzymeNucleotideMolecular biologyOrganic chemistryGeneBase sequenceAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBacteriophages and microbial interactions