Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury
Jinchao Wang, Lei Li, Jianye Xu, Dilmurat Gheyret, Kaiji Li, Xu Zhang, Haoran Jia, Ye Tian, Xiao Liu, Shenghui Li, Guili Yang, Yalong Gao, Ruilong Peng, Huajie Liu, Bin Liu, Jianfeng Zhuang, Cong Wang, Xin Chen, Yafan Liu, B. Chen, Chuan Huang, Yuhan Li, Xin Chen, Jianning Zhang, Jianning Zhang
Abstract
These findings identify TREM1 as a promising therapeutic target and illuminate a NET-driven crosstalk between vascular dysfunction and inflammatory cascades in the context of TBI, offering novel translational insights for mitigating secondary brain injury.
Topics & Concepts
VasospasmNeutrophil extracellular trapsTraumatic brain injuryExtracellularMedicineEndotheliumBrain damageBlood–brain barrierInflammationCardiologyPharmacologySubarachnoid hemorrhageAnesthesiaInternal medicineChemistryCentral nervous systemBiochemistryPsychiatryTraumatic Brain Injury and Neurovascular DisturbancesIntracranial Aneurysms: Treatment and ComplicationsNeutrophil, Myeloperoxidase and Oxidative Mechanisms