Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker
Aslan Mansurov, Peyman Hosseinchi, Kevin Chang, Abigail L. Lauterbach, Laura Gray, Aaron T. Alpar, Erica Budina, Anna J. Slezak, Seounghun Kang, Shijie Cao, Ani Solanki, Suzana Gomes, John‐Michael Williford, Melody A. Swartz, Juan L. Mendoza, Jun Ishihara, Jeffrey A. Hubbell
Topics & Concepts
Immune systemProteasesCancer researchCytokineImmunotherapyMelanomaBiologyProteaseInterleukinReceptorImmunologyMedicineEnzymeBiochemistryImmunotherapy and Immune ResponsesCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies Research