Copper-Catalyzed Selective Defluorinative Sulfuration of Trifluoropropanamides Leading to α-Fluorothioacrylamides
Xiaoqin Shen, Sui‐Qian Wang, Dongfeng Fan, Xing‐Guo Zhang, Hai‐Yong Tu
Abstract
A practical and efficient method for the synthesis of α-fluorothioacrylamide was developed from selective defluorinative sulfuration of trifluoropropanamides with disulfides. The N-chelation-assisted copper-catalyzed defluorination and sulfurization reactions feature excellent functional group tolerance and incorporation of both sulfur atoms of disulfides into acrylamides.
Topics & Concepts
ChemistryCopperCatalysisSulfurChelationFunctional groupCombinatorial chemistryOrganic chemistryPolymerFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCyclopropane Reaction Mechanisms