A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components
Monique B. Nilsson, Huiying Sun, Jacqulyne Robichaux, Matthias Pfeifer, Ultan McDermott, Jon Travers, Lixia Diao, Yuanxin Xi, Pan Tong, Li Shen, Mia Hofstad, Masanori Kawakami, Xiuning Le, Xi Liu, You-Hong Fan, Alissa Poteete, Limei Hu, Marcelo V. Negrão, Hai T. Tran, Ethan Dmitrovsky, David H. Peng, Don L. Gibbons, Jing Wang, John V. Heymach
Abstract
expression correlated with expression of genes encoding SAC proteins and was associated with a worse clinical outcome. These data revealed the YAP/FOXM1 axis as a central regulator of EMT-associated EGFR TKI resistance and that this pathway, along with SAC components, are therapeutic vulnerabilities for targeting this multidrug-resistant phenotype.
Topics & Concepts
FOXM1Cell biologyCancer researchChemistryBiologyCellCell cycleGeneticsHippo pathway signaling and YAP/TAZSignaling Pathways in DiseaseCancer-related gene regulation