Self-amplified ROS production from fatty acid oxidation enhanced tumor immunotherapy by atorvastatin/PD-L1 siRNA lipopeptide nanoplexes
Yan Gao, Zilin Song, Jia Li, Yi Tang, Chengcheng Wang, Xiuli Zhao, Haiyang Hu, Dawei Chen, Mingxi Qiao
Topics & Concepts
Reactive oxygen speciesAMPKMitochondrial ROSCancer cellAtorvastatinChemistryCell biologyTumor microenvironmentCancer researchBiochemistryBiologyProtein kinase APharmacologyPhosphorylationCancerGeneticsTumor cellsNanoplatforms for cancer theranosticsCancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism