1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum
Yanran Lu, Chelsea A. Mann, Sheri Nolan, Jessica A. Collins, Elizabeth M. Parker, Jonathan L. Papa, Sandip Vibhute, Seyedehameneh Jahanbakhsh, Mary Thwaites, David Hufnagel, Manzour Hernando Hazbón, Jane Moreno, Timothy T. Stedman, Thomas E. Wittum, Daniel J. Wozniak, Neil Osheroff, Jack C. Yalowich, Mark J. Mitton‐Fry
Abstract
Antibacterial resistance continues its devastation of available therapies. Novel bacterial topoisomerase inhibitors (NBTIs) offer one solution to this critical issue. Two series of amine NBTIs bearing tricyclic DNA-binding moieties as well as amide NBTIs with a bicyclic DNA-binding moiety were synthesized and evaluated against methicillin-resistant Staphylococcus aureus (MRSA). Additionally, these compounds and a series of bicyclic amine analogues displayed high activity against susceptible and drug-resistant Neisseria gonorrhoeae, expanding the spectrum of these dioxane-linked NBTIs.