Age- and sex-specific biomechanics and extracellular matrix remodeling of the ascending aorta in a mouse model of severe Marfan syndrome
Krashn Kumar Dwivedi, Jacob Rother, Jessica E. Wagenseil
Abstract
= MU) of severe thoracic aortic aneurysm in Marfan syndrome (MFS), we found that male MU aorta had an accelerated time line and increased amounts of dilatation, stiffening, and extracellular matrix (ECM) remodeling compared with female MU aorta that may have contributed to an increased risk of fatigue failure with cyclic loading over time and a reduced life span. We suggest that aortic stiffness may provide useful information for clinical management of aneurysms in MFS.
Topics & Concepts
Marfan syndromeAscending aortaBiomechanicsExtracellular matrixFibrillinAortaAnatomyMedicineInternal medicineCardiologyBiologyCell biologyConnective tissue disorders researchAortic Disease and Treatment ApproachesPulmonary Hypertension Research and Treatments