The J-elongated conformation of β2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome
Eliza A. Ruben, William Planer, Mathivanan Chinnaraj, Zhiwei Chen, Xiaobing Zuo, Vittorio Pengo, Vincenzo De Filippis, Ravi Kumar Alluri, Keith R. McCrae, Paolo Macor, Francesco Tedesco, Nicola Pozzi
Abstract
GPI provides a strategy to block pathogenic aPLs in APS.
Topics & Concepts
Antiphospholipid syndromeGlycoproteinChemistryMedicineAntibodyBiochemistryImmunologySystemic Lupus Erythematosus ResearchDiabetes and associated disordersCell Adhesion Molecules Research