A MOF/DNA luminescent sensing platform for detection of potential COVID-19 biomarkers and drugs
Xinrui Wang, Gilles Clavier, Yan Zhang, Kamal Batra, Nanan Xiao, Guillaume Maurin, Bin Ding, Antoine Tissot, Christian Serre
Abstract
and LOD is 54 nM), due to the fact that oseltamivir can disconnect the loop stem structure constructed by S2, leading to a strong quenching effect towards Y-MOF@S2@IL-6. The nature of the interactions between oseltamivir and Y-MOF has been elucidated using density functional theory calculations while the sensing mechanism for the dual detection of IL-6 and oseltamivir has been deciphered based on luminescence lifetime tests and confocal laser scanning microscopy.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)DNALuminescenceLuminescent MeasurementsNanotechnologyComputational biologyChemistryCombinatorial chemistryVirologyMaterials scienceBiologyMedicineBiochemistryOptoelectronicsInfectious disease (medical specialty)PathologyOutbreakDiseaseAdvanced biosensing and bioanalysis techniquesMetal-Organic Frameworks: Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis