Synthesis and Evaluation of Anticancer Activity of Pyrazolone Appended Triarylmethanes (TRAMs)
Rajpratap Kshatriya, Premchand B. Shelke, Suraj N. Mali, Gauravi Yashwantrao, Amit P. Pratap, Satyajit Saha
Abstract
Abstract The present work describes the design, synthesis, and evaluation of the anticancer properties of pyrazolone ring appended triarylmethanes by the condensation of diarylmethanols with pyrazolone in presence of a catalytic amount of p‐TSA catalyst. The use of an inexpensive catalyst and accessing the desired product in good yields within a short span are the merits associated with this protocol. Furthermore, the in‐silico, as well as in‐vitro analysis and molecular docking of the designed molecules, were performed followed by their anticancer activity evaluation against cancer cell lines like MCF7, MDA‐MB‐231, HeLa, and DU‐145. Few of the synthesized molecules demonstrated significant anticancer activity and could provide a new direction in the development of anti‐cancer molecules.