Fisetin mitigates letrozole-induced polycystic ovarian syndrome in rats: crosstalk of AMPK/PI3K/AKT-mediated-Nrf2 antioxidant defense mechanism and the inflammasome NLRP3/NF-κB P65/IL-1β signaling pathways
Passant E. Moustafa, Nesma M.E. Abo El- Nasr, Marwa E. Shabana, Dalia O. Saleh
Topics & Concepts
AMPKProinflammatory cytokineFisetinPI3K/AKT/mTOR pathwayProtein kinase BEndocrinologyPolycystic ovaryInflammasomeDownregulation and upregulationInternal medicineMedicineHormoneSignal transductionInsulin resistanceBiologyAntioxidantInflammationInsulinProtein kinase APhosphorylationCell biologyGeneFlavonoidBiochemistryInflammasome and immune disordersLipid metabolism and disordersOvarian function and disorders