Taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid X receptor
Yi‐Chun Liu, Kai‐Min Niu, Ruxia Wang, Xiao‐Xiao Liang, Chong Lin, X. Wu, Zhenya Zhai
Abstract
Bile acids, such as taurochenodeoxycholic acid (TCDCA), are considered as functional small molecules involved in nutrition regulation or acting with adjuvant therapeutic effects against metabolic or immune diseases.
Topics & Concepts
Farnesoid X receptorApoptosisOccludinCell growthCancer researchCell biologyInternal medicineEndocrinologyMolecular biologyChemistryBiologyTight junctionMedicineNuclear receptorBiochemistryTranscription factorGeneDrug Transport and Resistance MechanismsPharmacological Effects of Medicinal PlantsCholesterol and Lipid Metabolism