Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA
Xin Liu, Fanyu Meng, Rui Sun, Kang‐Nan Wang, Zhiqiang Yu, Peng Miao
Abstract
In this work, we have developed a simple and reliable platform for simultaneous analysis of telomerase and miRNA. A three-dimensional bipedal DNA walking strategy is designed utilizing gold nanoparticles and MnO2 nanosheets. Given the merits of fast, sensitive and selective analysis, the developed method has great potential application in early clinical diagnosis.
Topics & Concepts
TelomerasemicroRNADNAComputer scienceCell biologyBiologyComputational biologyNeuroscienceChemistryBiological systemNanotechnologyMaterials scienceGeneticsGeneAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBiosensors and Analytical Detection