Elabela alleviates myocardial ischemia reperfusion-induced apoptosis, fibrosis and mitochondrial dysfunction through PI3K/AKT signaling.
Peng Yu, Sicong Ma, Xinchun Dai, Feng Cao
Abstract
. After treatment with Elabela or Elabela combined with LY294002, the levels of oxidative stress and apoptosis were examined. The results revealed that Elabela significantly improved the pathological changes of rat myocardial tissues induced by I/R. Additionally, Elabela treatment reduced cardiomyocyte I/R induced fibrosis and apoptosis as well as ameliorated mitochondrial dysfunction in animal and cells. Within inhibition of PI3K pathway, the protective effects of Elabela was reversed. Taken together, these findings demonstrated that Elabela could protect against fibrosis, apoptosis and oxidative stress via PI3K/ATK signaling pathway in cardiac ischemia reperfusion.
Topics & Concepts
PI3K/AKT/mTOR pathwayMasson's trichrome stainFibrosisMyocardial fibrosisApoptosisOxidative stressMedicineMyocardial infarctionTUNEL assayProtein kinase BIschemiaIn vivoCardiac fibrosisInternal medicineCardiologyPharmacologyImmunohistochemistryChemistryBiologyBiochemistryBiotechnologyApelin-related biomedical researchCardiovascular, Neuropeptides, and Oxidative Stress ResearchParaoxonase enzyme and polymorphisms