Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA<sup>+</sup> interstitial cells are fibroblasts
Dennis R. Clayton, Wily G. Ruiz, Marianela G. Dalghi, Nicolás Montalbetti, Marcelo D. Carattino, Gerard Apodaca
Abstract
We currently lack basic insights into the fibroblasts that populate the bladder wall. By exploring the ultrastructure of mouse bladder connective tissue cells, combined with analyses of their gene and protein expression, our study revealed that PDGRA + interstitial cells (also referred to as myofibroblasts, telocytes, and interstitial cells of Cajal-like cells) are fibroblasts and that the bladder wall contains multiple, regionally distinct populations of these cells.
Topics & Concepts
PDGFRAFibroblastBiologyInterstitial cellCD34Interstitial cell of CajalCell biologyMyofibroblastEndoplasmic reticulumPathologyUltrastructureMolecular biologyImmunohistochemistryCell cultureCancer researchStromal cellImmunologyAnatomyFibrosisStem cellMedicineGeneticsEndocrinologyGiSTTissue Engineering and Regenerative MedicineUrinary Bladder and Prostate ResearchUrological Disorders and Treatments