A triterpenoid-enriched extract of bitter melon leaves alleviates hepatic fibrosis by inhibiting inflammatory responses in carbon tetrachloride-treated mice
Mei-Ling Chang, Yu-Ting Lin, Hsiu‐Ni Kung, Yu-Chen Hou, Jun‐Jen Liu, Min‐Hsiung Pan, Hui‐Ling Chen, Chun-Hsien Yu, Po‐Jung Tsai
Abstract
monocyte infiltration. We demonstrated that TEE could ameliorate hepatic fibrosis by regulating inflammatory cytokine secretion and α-SMA expression in the liver to reduce collagen accumulation.
Topics & Concepts
Carbon tetrachlorideCCL4Hepatic fibrosisFibrosisEndocrinologyInternal medicineIntraperitoneal injectionChemistryMedicinePathologyOrganic chemistryLiver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation