In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes
Luca Docci, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Kenichi Umehara, Isabelle Walter, Stephan Krähenbühl, Neil Parrott, Stephen Fowler
Topics & Concepts
In vivoIn vitroClearancePharmacokineticsChemistryPharmacologyCytochrome P450Drug metabolismClearance rateMetabolic clearance rateEnzymeBiophysicsBiochemistryBiologyMedicineEndocrinologyUrologyBiotechnologyPharmacogenetics and Drug MetabolismAnalytical Chemistry and ChromatographyDrug Transport and Resistance Mechanisms