Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimer's disease
Wei Xu, Alzheimer’s Disease Neuroimaging Initiative, Bing‐Jie Su, Xue‐Ning Shen, Yanlin Bi, Chen‐Chen Tan, Jieqiong Li, Xi‐Peng Cao, Qiang Dong, Lan Tan, Jin‐Tai Yu
Abstract
4 allele, and cognitive scores. Though no significant difference of plasma SHBG was observed between mild AD dementia and healthy normal, plasma SHBG could contribute to accelerated rates of CSF Aβ42 decrease (p < 0.0005), decline in brain metabolism (p < 0.05), and hippocampus atrophy (p < 0.01), cognitive decline (p < 0.01), as well as higher risk of AD dementia (p < 0.05). These findings indicated plasma SHBG could be a prodromal biomarker to predict disease progression in AD.
Topics & Concepts
NeurodegenerationSex hormone-binding globulinAlzheimer's diseaseDiseaseMedicineInternal medicineHormoneEndocrinologyAndrogenBiochemical effects in animalsAlzheimer's disease research and treatmentsPhytoestrogen effects and research