LDL-C plays a causal role on T2DM: a Mendelian randomization analysis
Wenbin Pan, Weiju Sun, Shuo Yang, He Zhuang, Huijie Jiang, Hong Ju, Donghua Wang, Ying Han
Abstract
) were deleted, with the remaining 23 SNPs without LD eventually being deemed as IVs. The combined effect of all these 23 SNPs on T2DM, as generated with use of the penalized robust inverse-variance weighted (IVW) method (Beta value 0.24, 95%CI 0.087~0.393, P-value=0.002) demonstrated that elevated LDL-C levels significantly increased the risk of T2DM. The relationship between LDL-C and Type 1 diabetes mellitus (T1DM) with this analysis producing negative pooled results (Beta value -0.202, 95%CI -2.888~2.484, P-value=0.883).
Topics & Concepts
Mendelian randomizationDyslipidemiaSingle-nucleotide polymorphismType 2 Diabetes MellitusInternal medicineType 2 diabetesDiabetes mellitusMedicineGeneticsBiologyEndocrinologyGeneGenetic variantsGenotypeGenetic Associations and EpidemiologyLipoproteins and Cardiovascular HealthLipid metabolism and disorders