Cryo-EM structure of the human heteromeric amino acid transporter b <sup>0,+</sup> AT-rBAT
Renhong Yan, Yaning Li, Yi Shi, Jiayao Zhou, Jianlin Lei, Jing Huang, Qiang Zhou
Abstract
AT-rBAT exists as a dimer of heterodimer consistent with the previous study. A ligand molecule is bound to the substrate binding pocket, near which an occluded pocket is identified, to which we found that it is important for substrate transport.
Topics & Concepts
Transmembrane proteinAmino acidTransporterDisulfide bondChemistryTransmembrane domainBiochemistryAmino acid transporterChain (unit)StereochemistryGenePhysicsAstronomyReceptorAmino Acid Enzymes and MetabolismRNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry