YejM Controls LpxC Levels by Regulating Protease Activity of the FtsH/YciM Complex of Escherichia coli
Daniel Nguyen, Keilen Kelly, Nan Qiu, Rajeev Misra
Abstract
Lipid homeostasis is critical for proper envelope functions. The level of LpxC, which catalyzes the first committed step of lipopolysaccharide (LPS) synthesis, is controlled by an essential protease complex comprised of FtsH and YciM. Work carried out here suggests YejM, an essential envelope protein, plays a central role in sensing the state of LPS synthesis and controls LpxC levels by regulating the activity of FtsH/YciM. All four essential proteins are attractive targets of therapeutic development.
Topics & Concepts
BiologyEscherichia coliProteaseMicrobiologyBiochemistryEnzymeGeneEscherichia coli research studiesBacterial Genetics and BiotechnologyRNA and protein synthesis mechanisms