Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration
Manling Xie, Yue Liang, Alessandra S. Miller, Praveen N. Pallegar, Anthony D. Umpierre, Na Wang, Shuwen Zhang, Nagaswaroop Kengunte Nagaraj, Zachary C. Fogarty, Nikhil B Ghayal, Björn Oskarsson, Shunyi Zhao, Jiaying Zheng, Shi Wu, Mastura Akter, Fangfang Qi, Aivi T. Nguyen, Dennis W. Dickson, Long‐Jun Wu
Topics & Concepts
MicrogliaNeurodegenerationNeuroscienceBiologyNeuroprotectionPremovement neuronal activityGenetically modified mouseCalcium imagingCentral nervous systemExcitatory postsynaptic potentialImmune systemTransgeneNeuroplasticityHuman brainReceptorNeuronSynapseCortical neuronsLong-term potentiationCell biologyCerebral cortexIn vivoNeurotransmissionNeuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysNeurogenesis and neuroplasticity mechanisms