Synthesis and anticancer mechanisms of four novel platinum(<scp>ii</scp>) 4′-substituted-2,2′:6′,2′′-terpyridine complexes
Chun-Jie Liang, Run-Chun Wu, Xiaoqiong Huang, Qi‐Pin Qin, Hong Liang, Ming‐Xiong Tan
Abstract
. 52.4%) and almost no toxicity. Therefore, the new 4'-substituted-2,2':6',2''-terpyridine Pt(II) coordination compound (tpy1Pt) is a potential candidate for next-generation mitophagy-targeting dinuclear Pt(II)-based anticancer drugs.
Topics & Concepts
TerpyridineIn vivoPlatinumIn vitroChemistryCisplatinCombinatorial chemistryMitophagyStereochemistryBiochemistryBiologyMetalOrganic chemistryCatalysisChemotherapyMedicineApoptosisInternal medicineBiotechnologyAutophagyMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsSynthesis and biological activity