Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer
Fangbin Zhang, Yan Yan, Xinguang Cao, Jinping Zhang, Yingxia Li, Changqing Guo
Abstract
experiments validated that EED promoted the progression of GC through mediating the miR-338-5p/METTL3/CDCP1 axis. Collectively, EED downregulated miR-338-5p through histone methylation, which in turn impaired miR-338-5p-dependent METTL3 inhibition and enhanced CDCP1 translation, therefore contributing to the development of GC.
Topics & Concepts
microRNAMethylationCancer researchTranslation (biology)OncogeneCancerDNA methylationBiologyGeneticsDNAMessenger RNAGeneGene expressionCell cycleRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation