Mutation detection and molecular targeted tumor therapies
Yamin Wang, Zhong Chen
Abstract
Rapid advancement in genomic technologies has greatly enhanced the potential of clinical recognition and application of molecular targets. Specifically, gene mutation detection technologies are of great significance in the early diagnosis, customized drug delivery guidance, treatment progression, and monitoring of tumor’s drug resistance. Gene mutation detection or genetic typing of patients is a prerequisite for molecular targeted therapies. Most kinds of targeted therapies treat cancers by interfering with specific proteins that are involved in tumorigenesis. Compared with traditional chemotherapies, molecular targeted therapies have many advantages, despite that they still have risks of resistance, side effects and leak of genetic information.