Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5
Anthony Tumber, E. Salah, Lennart Brewitz, Thomas P. Corner, Christopher J. Schofield
Abstract
roxadustat) do not inhibit JMJD5. The SPE-MS assays will help enable the development of efficient and selective JMJD5 inhibitors for investigating the biochemical functions of JMJD5 in cellular studies.
Topics & Concepts
Kinetic energyChemistryDomain (mathematical analysis)BiochemistryBiophysicsBiologyPhysicsMathematicsMathematical analysisQuantum mechanicsPharmacogenetics and Drug MetabolismMitochondrial Function and PathologyCancer, Hypoxia, and Metabolism