Development of CAR-T cell therapy for B-ALL using a point-of-care approach
Luiza Abdo, Luciana Rodrigues Carvalho Barros, Mariana Saldanha Viegas, Luísa Vieira Codeço Marques, Priscila de Sousa Ferreira, Leonardo Chicaybam, Martín Bonamino
Abstract
. Our data suggest that POC approach is a viable alternative for the generation and use of CAR-T cells, overcoming the limitations of current manufacturing protocols. Its use has the potential to expand CAR immunotherapy to a higher number of patients, especially in the context of low-income countries.
Topics & Concepts
ElectroporationChimeric antigen receptorImmunotherapyMedicineT cellIn vivoGenetic enhancementEx vivoCell therapyCancer researchImmunologyBiologyImmune systemStem cellGeneCell biologyBiotechnologyBiochemistryCAR-T cell therapy researchVirus-based gene therapy researchViral Infectious Diseases and Gene Expression in Insects