Fibroblast-derived LPP as a biomarker for treatment response and therapeutic target in gastric cancer
Hao Wang, Jing Wu, Ruoyu Ling, Fengping Li, Qingbin Yang, Jiayong He, Xuetao Lei, Chaorui Wu, Guofan Zhang, Boyang Zheng, Yanmei Peng, Yihao Zhang, Hao Chen, Gengtai Ye, Guoxin Li
Abstract
memory T cell infiltration and tumor growth. High-LPP patients yielded fewer benefits from chemotherapy or immunotherapy, compared with the low-LPP group. We finally identified 28 compounds as sensitive drugs for high-LPP patients. Our findings suggested LPP might be a biomarker for treatment response and therapeutic target in gastric cancer.
Topics & Concepts
Immune systemImmunotherapyOncologyBiomarkerCancer researchTumor microenvironmentCancerMedicineChemotherapyInternal medicineImmunologyBiologyBiochemistryCancer Immunotherapy and BiomarkersGastrointestinal Tumor Research and TreatmentImmune Cell Function and Interaction