Synthesis and sequencing of informational poly(amino phosphodiester)s
Ian Roszak, Laurence Oswald, Abdelaziz Al Ouahabi, Annabelle Bertin, Eline Laurent, Olivier Félix, Isaure Sergent, Laurence Charles, Jean‐François Lutz
Abstract
The inclusion of main-chain tertiary amines in digital poly(phosphodiester)s allows synthesis of molecularly-defined achiral polymers and simplifies tandem mass spectrometry sequencing.
Topics & Concepts
Phosphodiester bondChemistryCombinatorial chemistryComputational biologyStereochemistryBiochemistryBiologyRNAGeneChemical Synthesis and AnalysisDiatoms and Algae ResearchMass Spectrometry Techniques and Applications