Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system
Qian Luo, Jiaying Yang, Mei Yang, Yu Wang, Yiran Liu, Ji‐Xuan Liu, Dhan V. Kalvakolanu, Xianling Cong, Jinnan Zhang, Ling Zhang, Baofeng Guo, Yanhong Duo
Abstract
Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS diseases is extremely challenging. Nano-delivery systems can overcome the limitations of BBB to deliver drugs to the CNS, improve the ability of drugs to target the brain and provide potential therapeutic methods for CNS diseases. At the same time, the choice of different drug delivery methods (bypassing BBB or crossing BBB) can further optimize the therapeutic effect of the nano-drug delivery system. This article reviews the different methods of nano-delivery systems to overcome the way BBB enters the brain. Different kinds of nanoparticles to overcome BBB were discussed in depth. Diagram of nanotechnologies in surmounting the blood-brain barrier in the disorders of the central nervous system. • Nano-delivery systems can overcome the limitations of BBB to deliver drugs to the central nervous system (CNS) diseases. • Different kinds of nano-delivery systems have great capability to bypass or cross BBB with different molecular mechanism. • These nano-delivery systems are capable for optimizing the therapeutic effects.