Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
Silvia Jesús, Miguel A. Labrador‐Espinosa, A. D. Adarmes, Carmen Barrio, Juan Carlos Martínez‐Castrillo, Araceli Alonso‐Cánovas, Pilar Sánchez Alonso, Sabela Novo-Ponte, Maria Gema Alonso-Losada, Núria López Ariztegui, J. C. Segundo Rodríguez, María Ibis Rivera Morales, Itziar Gastón, F. Lacruz Bescos, P. Clavero Ibarra, Jaime Kulisevsky, Javier Pagonabarraga, Berta Pascual‐Sedano, Pablo Martínez‐Martín, Diego Santos‐García, Mir P, COPPADIS Study Group, M. Aguilar, Marta Almería, María Álvarez Saúco, S. Arnáiz, Sonia López Arribas, A. Ascunce Vidondo, N. Bernardo, Helena Bejr‐Kasem, Marta Blázquez Estrada, M. Botí, Carmen Borrué, C. Cabello González, A. Cámara Lorenzo, F. Carrillo, Francisco Carrillo Padilla, Erik Jesús Huánuco Casas, M. J. Catalán, A. Cortina Fernández, A. Cots Foraster, A. Crespo Cuevas, Esther Cubo, Mónica Díez-Fairén, Sonia Escalante, Elena Erro, O. de Fábregues-Boixar, N. Fernández Guillán, P. Gámez, M. Gallego, Juan García Caldentey, Cristina Campos, J M García-Moreno, M. P. Gómez Garre, J. González Aloy, Jessica González Ardura, B. González García, M. J. González Palmás, G. R. González Toledo, Adam Diaz, M. Grau Solá, G. Guardia, Andrea Horta‐Barba, Jon Infante, Mónica Kurtis, Jorge Hernández‐Vara, Carmen M. Labandeira, M. Lage Castro, Inés Legarda, L. M. López Díaz, Lydia López Manzanares, B. López Seoane, Yolanda Macías, M. Mata, G. Martí Andres, Marı́a José Martı́, Darrian McAfee, M. T. Meitín, Manuel Menéndez‐González, J. Miranda Santiago, Antonio Moreno Diéguez, Víctor Nogueira, A. Novo Amado, Carlos Ordás, P. Pastor, Jose Manuel Paz González, Isabel Pareés, A. Pérez Fuertes, R. Pérez Noguera, Lluís Planellás, M. A. Prats, C. Prieto Jurczynska, María Pueyo, Víctor Puente, N. Redondo Rafales, Lorena Méndez, A. B. Rodríguez Pérez, F Pérez Roldán, M. Ruíz De Arcos, J. Ruíz Martínez
Abstract
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.