Litcius/Paper detail

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Nicholas Yagoda, Moritz von Rechenberg, Elma Zaganjor, Andras J. Bauer, Wan Seok Yang, Daniel J. Fridman, Adam J. Wolpaw, Inese Smukste, John M. Peltier, J. Jay Boniface, Richard A. Smith, Stephen L. Lessnick, Sudhir Sahasrabudhe, Brent R. Stockwell

2007Nature1,626 citationsDOIOpen Access PDF

Topics & Concepts

Voltage-dependent anion channelVDAC1Gene knockdownCell biologyProgrammed cell deathCancer cellSynthetic lethalityKRASMitochondrionApoptosisBiologyChemistryCancer researchBiochemistryCancerMutationBacterial outer membraneGeneticsDNA repairGeneEscherichia coliNeuroscience and Neuropharmacology ResearchMelanoma and MAPK PathwaysRetinal Development and Disorders