<i>LOXL1</i> gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia.
Natalya Eliseeva, Irina Ponomarenko, Evgeny Reshetnikov, Volodymyr Dvornyk, Mikhail Churnosov
Abstract
Purpose: gene polymorphisms with exfoliation glaucoma (XFG) and to analyze these genetic variants for their possible contribution to primary open-angle glaucoma (POAG) in Caucasians from central Russia. Methods: gene (rs2165241, rs4886776, and rs893818). The association was analyzed using logistic regression. Results: =0.001). Conclusions: gene showed association with XFG and POAG in a Caucasian sample from central Russia.
Topics & Concepts
HaplotypeSingle-nucleotide polymorphismGlaucomaMedicineOdds ratioAlleleOpen angle glaucomaInternal medicineGenotypeGeneticsGastroenterologyOphthalmologyBiologyGeneGlaucoma and retinal disordersRetinal Diseases and TreatmentsOcular Surface and Contact Lens