Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights
Yasmin S. Sheta, Marwa T. Sarg, Fatma G. Abdulrahman, Eman S. Nossier, Ebtehal M. Husseiny
Topics & Concepts
ChemistryKinaseCytotoxicityDual (grammatical number)Combinatorial chemistryBiochemistryIn vitroArtLiteratureSynthesis and biological activityCancer therapeutics and mechanismsBioactive Compounds and Antitumor Agents