DARK Classics in Chemical Neuroscience: Kava
Andrey D. Volgin, Longen Yang, Tamara G. Amstislavskaya, Konstantin A. Demin, Dongmei Wang, Dongni Yan, Jingtao Wang, Mengyao Wang, Erik T. Alpyshov, Guojun Hu, Nazar Serikuly, Вадим А. Шевырин, Edina A. Wappler-Guzzetta, Murilo S. de Abreu, Allan V. Kalueff
Abstract
) is a common drug-containing plant in the Pacific islands. Kavalactones, its psychoactive compounds, exert potent central nervous system (CNS) action clinically and in animal models. However, the exact pharmacological profiles and mechanisms of action of kava on the brain and behavior remain poorly understood. Here, we discuss clinical and experimental data on kava psychopharmacology and summarize chemistry and synthesis of kavalactones. We also review its societal impact, drug use and abuse potential, and future perspectives on translational kava research.