Cyanomethylative cyclization of unactivated alkenes with nitriles for the synthesis of cyano-containing ring-fused quinazolin-4(3<i>H</i>)-ones
Han Liu, Zixian Yang, Gao Huang, Jin‐Tao Yu, Changduo Pan
Abstract
The synthesis of cyano-containing pyrrolo- and piperidino-quinazolinones was developed using alkyl nitriles through radical cascade addition/cyclization under metal-free conditions.
Topics & Concepts
ChemistryRing (chemistry)Radical cyclizationCascadeAlkylStereochemistryCombinatorial chemistryMedicinal chemistryNitrileOrganic chemistryChromatographyQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic Chemistry