Innovative IgG Biomarkers Based on Phage Display Microbial Amyloid Mimotope for State and Stage Diagnosis in Alzheimer’s Disease
Laura Maria De Plano, Santina Carnazza, Domenico Franco, Maria Giovanna Rizzo, Sabrina Conoci, Salvatore Petralia, Alessandra Nicoletti, Mario Zappia, Michela Campolo, Emanuela Esposito, Salvatore Cuzzocrea, Salvatore Guglielmino
Abstract
-induced cytotoxicity in SH-SY5Y cells, as well as to promote disaggregation of preformed fibrils, to a greater extent with respect to wild-type phage (pC89). IgG levels detected by 12III1 provided a significant level of discrimination between diseased and nondemented subjects, as well as a good correlation with the state progression of the disease. These results give significant impact in AD state and stage diagnosis, paving the way for the development not only for an innovative blood diagnostic assay for AD precise diagnosis, progressive clinical assessment, and screening but also for new effective treatments.