Multicomponent cascade reactions of HKAs: synthesis of highly functionalized 5<i>H</i>-chromeno[4,3-<i>d</i>]pyrimidines
Yun-Xiang Fan, Xin-Ling Cao, Li Chen, Yihua Chen, Sheng‐Jiao Yan
Abstract
A novel protocol was developed for the construction of functionalized 5<italic>H</italic>-chromeno[4,3-<italic>d</italic>]pyrimidines from 3-formylchromones, heterocyclic ketene aminals, and amidine hydrochlorides <italic>via</italic> a novel cascade reaction involving ring-opening and 1,3-H shift reactions.
Topics & Concepts
ChemistryCascadeCombinatorial chemistryCascade reactionComputational chemistryMedicinal chemistryOrganic chemistryCatalysisChromatographyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityChemical Synthesis and Analysis