Rigid 3D-spiro chromanone as a crux for efficient antimicrobial agents: synthesis, biological and computational evaluation
Fathi Hamed Elghareeb, E. M. Kandil, M. Abou-Elzahab, Mohamed Abdelmoteleb, Mohamed Ahmed Abozeid
Abstract
-beta-1,3-glucanase (-8.2 to -11.9 kcal). The QSAR analysis ascertained a good correlation between the antimicrobial activity of 3D-spiro chromanone derivatives and their structural and/or physicochemical parameters.
Topics & Concepts
HydrazoneHydrazideAntimicrobialChemistryReagentBenzaldehydeYield (engineering)Hydrazine (antidepressant)SalicylaldehydeCombinatorial chemistryStereochemistryMedicinal chemistryNuclear chemistryOrganic chemistryChromatographyMaterials scienceSchiff baseMetallurgyCatalysisSynthesis and biological activityMulticomponent Synthesis of HeterocyclesClick Chemistry and Applications