Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis
Hongyi Zhao, Bin Wang, Lei Fu, Gang Li, Haijia Lu, Yuke Liu, Sheng Li, Yan Li, Baoxi Zhang, Yang Lü, Chen Ma, Haihong Huang, Dongfeng Zhang, Yu Lu
Abstract
appeared to have less bone marrow suppression than linezolid, which has been a major liability of the oxazolidinone class.
Topics & Concepts
DruggabilityPharmacologyChemistryhERGIn vivoCytochrome P450RifampicinEnzymeBiochemistryMedicineAntibioticsBiologyGeneticsEndocrinologyGenePotassium channelTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsBiochemical and Molecular Research