Environmental and intrinsic factors shaping gut microbiota composition and diversity and its relation to metabolic health in children and early adolescents: A population-based study
Sofía Morán‐Ramos, Blanca E. López-Contreras, Ricardo Villarruel‐Vazquez, Elvira Ocampo‐Medina, Luis Macías‐Kauffer, Jennifer N. Martínez-Medina, Hugo Villamil‐Ramírez, Paola León‐Mimila, Blanca E. Del-Río-Navarro, Isabel Ibarra‐González, Marcela Vela‐Amieva, Francisco J. Gómez‐Pérez, Rafael Velázquez‐Cruz, Jorge Salmerón, Zyanya Reyes-Castillo, Carlos A. Aguilar‐Salinas, Samuel Canizales‐Quinteros
Abstract
BACKGROUND: Gut microbiota, by influencing multiple metabolic processes in the host, is an important determinant of human health and disease. However, gut dysbiosis associated with metabolic complications shows inconsistent patterns. This is likely driven by factors shaping gut microbial composition that have largely been under-evaluated, at a population level, in school-age children, especially from developing countries. RESULTS: 0.409, respectively). Finally, co-abundance groups (CAGs) were associated with the presence of metabolic complications. CONCLUSIONS: Our study offers evidence that the presence of overweight and obesity could impair the microbial diversity maturation associated with age. Furthermore, it provides novel results toward a better understanding of gut microbiota in the pediatric population that will ultimately help to develop therapeutic approaches to improve metabolic status.